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Prognostic value of a plasma protein-based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians

Timothy M. E. Davis,1,2,3 Kirsten E. Peters,4 Scott Bringans,4 Daniel McAullay,5 Arvind Singh,4Richard J. Lipscombe4 and Wendy A. Davis1,3

Summary

The predictive value of PromarkerD tests for incident diabetic kidney disease or rapid decline in estimated glomerular filtration rate was evaluated in 1010 non-Aboriginal and 71 Aboriginal adults with diabetes. Areas under the receiver operating characteristic curves were not significantly different (P ≥ 0.081) for first- (non-Aboriginals 0.890 (95% confidence interval 0.864 to 0.915) and Aboriginals 0.769 (0.624 to 0.915)) and secondgeneration (0.890 (0.862 to 0.917) and 0.711 (0.543 to 0.878)) tests. PromarkerD has potential renal prognostic value in Aboriginals with diabetes.

Key Points

  • The burden of diabetes-related chronic kidney disease is around seven times higher in Aboriginal Australians than in non-Indigenous Australians.

  • PromarkerD accurately predicted decline in kidney function in Aboriginal adults with diabetes (AUC 0.71).

  • PromarkerD demonstrated a negative predictive value >85%, reliably identifying people unlikely to experience near-term kidney decline.

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